> 1. If we have "enough" "orthogonal" treatment options, we should be able to rotate on long enough time scales to avoid resistance to all treatments. Like cica

> 1. If we have "enough" "orthogonal" treatment options, we should be able to rotate on long enough time scales to avoid resistance to all treatments. Like cicadas with their prime numbered long sleep cycles. This is something that has crossed my mind in the past. We rotate antibiotics in a logical fashion, in a manner similar to the way we rotate crops. But as someone else responded more eloquently, you're gonna have a hard time telling grandma's family that the most effective antibiotic is currently "out of rotation." And honestly, I'd be pretty upset if it were my grandma, too.