> Certainly not implying it's impossible, I agree. Never say "never." But a lot of the time, resistance is simply a matter of tinkering with target of the ant

> Certainly not implying it's impossible, I agree. Never say "never." But a lot of the time, resistance is simply a matter of tinkering with target of the antibiotic (add a methyl group here and, voila! the antibiotic no longer binds effectively). Then there are multi-drug efflux pumps (https://en.wikipedia.org/wiki/Efflux_(microbiology) https://en.wikipedia.org/wiki/Efflux_(microbiology)) that "indiscriminately" toss shit out of the bacterial cell.