Yeah these have been the hot thing for a minute. Nina Tandons TED talk came out 10 years ago and minus a few more detailed developments, I think it holds up rea

Yeah these have been the hot thing for a minute. Nina Tandons TED talk came out 10 years ago and minus a few more detailed developments, I think it holds up really well as an introduction. The main challenges are related to the fact that cell cultures and tissue cultures are also not easy to standardize (passaging and media variations) and also introducing mechanical stimuli to more accurately model living systems. Serum free media is one area where there's been a bit of development, and recreating function mechanically has been a really interesting field. Dongeun Huh's paper I think he did while a postdoc in Donald Ingbers lab is pretty canonical and still is incredibly impressive but stretching is only part of the deformations these tissues undergo.