> Even if the estimate is accurate, there is a massive qualitative difference between slowly dying horribly for 'x' years and living a normal life for 'y' years

> Even if the estimate is accurate, there is a massive qualitative difference between slowly dying horribly for 'x' years and living a normal life for 'y' years. The difference in measured in QALYs - quality-adjusted life years. The study attempts to take that into account. > They can't possibly know that the drug extends life to "22.74" years, because it has only been approved for use for the last 3 years! This is like asking for 30 years of Kubernetes experience on a job application. Yes, exactly my point. The long-term effects of this treatment are what will make it worthwhile or not. Trying to extrapolate a few years to a full life does not make that an easy exercise.