3 ms·

(A step forward in) understanding "Fragile X syndrome" which is a type of autism. But I'm not sure how many of people with an autism diagnosis has FXS

nailer 4y ago
The article says FXS is the most common cause. But that seems odd. Wikipedia has two references for; > Fragile X syndrome (FXS) is a genetic disorder characterized by mild-to-moderate intellectual disability. The average IQ in males with FXS is under 55. That doesn’t sound like most autistics I know.
mnw21cam 4y ago
Fragile X is about 1.4 cases per 10,000 males. Autism is way more common than that, so I wouldn't say the Fragile X accounts for even a single percent of Autism cases. The article saying that it is the most common cause of Autism is definitely weasle-wording, and can only be claimed because most autism is not monogenic in nature. It's almost always a polygenic trait, and therefore doesn't have a single "identified" cause.
- kevviiinn 4y ago
  Not exactly, currently under the DSM there are a whole bunch of related behavioral phenotypes that are grouped under the ASD umbrella. This includes similar behavioral patterns and processing issues. Yes sometimes it can be polygenic but the reality is that there are a whole bunch of different things that can cause similar behaviors and sensory processing issues. The DSM (and psychology in general) is still pretty shitty in the way that it groups things based on phenotype rather than mechanism
  - mnw21cam 4y ago
    Yeah, sorry. s/polygenic/not monogenic/
diydsp 4y ago
Yes def worth skimming about fxs.(1) Avg iq of fxs males is 55. This isn't "trains" autism. It's a full-disability. Still very important news! (1) https://en.m.wikipedia.org/wiki/Fragile_X_syndrome https://en.m.wikipedia.org/wiki/Fragile_X_syndrome
mrangle 4y ago
I'm in a medical profession that delivers services to the autistic community. Never in our training did we learn that Fragile X is a cause of autism, let alone the primary cause. I've never delivered services to a client that had a diagnosis of both fragile x and autism. Most autism clients that I see are severely disabled and not fragile x. Every once in a while we get an HFA client. Again, no fragile x. The Asperger's individuals that I come across in the clinic will tend to be clinical professionals, not clients. They are never in for services. But they aren't common either.

nailer 4y ago

The article says FXS is the most common cause. But that seems odd. Wikipedia has two references for; > Fragile X syndrome (FXS) is a genetic disorder characterized by mild-to-moderate intellectual disability. The average IQ in males with FXS is under 55. That doesn’t sound like most autistics I know.

mnw21cam 4y ago

Fragile X is about 1.4 cases per 10,000 males. Autism is way more common than that, so I wouldn't say the Fragile X accounts for even a single percent of Autism cases. The article saying that it is the most common cause of Autism is definitely weasle-wording, and can only be claimed because most autism is not monogenic in nature. It's almost always a polygenic trait, and therefore doesn't have a single "identified" cause.

kevviiinn 4y ago
Not exactly, currently under the DSM there are a whole bunch of related behavioral phenotypes that are grouped under the ASD umbrella. This includes similar behavioral patterns and processing issues. Yes sometimes it can be polygenic but the reality is that there are a whole bunch of different things that can cause similar behaviors and sensory processing issues. The DSM (and psychology in general) is still pretty shitty in the way that it groups things based on phenotype rather than mechanism
- mnw21cam 4y ago
  Yeah, sorry. s/polygenic/not monogenic/

diydsp 4y ago

Yes def worth skimming about fxs.(1) Avg iq of fxs males is 55. This isn't "trains" autism. It's a full-disability. Still very important news! (1) https://en.m.wikipedia.org/wiki/Fragile_X_syndrome https://en.m.wikipedia.org/wiki/Fragile_X_syndrome

mrangle 4y ago

I'm in a medical profession that delivers services to the autistic community. Never in our training did we learn that Fragile X is a cause of autism, let alone the primary cause. I've never delivered services to a client that had a diagnosis of both fragile x and autism. Most autism clients that I see are severely disabled and not fragile x. Every once in a while we get an HFA client. Again, no fragile x. The Asperger's individuals that I come across in the clinic will tend to be clinical professionals, not clients. They are never in for services. But they aren't common either.