if the adblock you're using is ublock origin then you can add this to your filters to block shorts on the homepage www.youtube.com##.ytd-rich-section-renderer.

if the adblock you're using is ublock origin then you can add this to your filters to block shorts on the homepage www.youtube.com##.ytd-rich-section-renderer.style-scope > .ytd-rich-shelf-renderer.style-scope there's probably more filters to block shorts in other places like the suggestions sidebar if you look for them, but i have the sidebar disabled completely so the above filter was enough for me