I've spent about 10 years doing research into brain metabolism and Alzheimer's. This is an interesting paper! It explains a lot of observed phenomena in the nov

I've spent about 10 years doing research into brain metabolism and Alzheimer's. This is an interesting paper! It explains a lot of observed phenomena in the novel context of fructose metabolism. I certainly am convinced that fructose has short-term effects on regional brain activity and whole-body metabolism. However they don't make great links between fructose and known AD pathology. Beta-amyloid buildup is now pretty convincingly a critical step in the progression of AD. They link a few low-quality papers claiming fructose increases amyloid, but the evidence is pretty weak. Similarly, APOE genotypes are well documented AD risk factors. The authors aren't really able to explain APOE's role in the context of fructose. Fun read (for me, anyway), but not particularly convincing. Hopefully it provokes some more research to try to fill in some of the missing links.