how do you expect we will ever get a randomized control trial controlling for fructose in diet? Your right, but RCT would take how long? 50 years? How can you

how do you expect we will ever get a randomized control trial controlling for fructose in diet? Your right, but RCT would take how long? 50 years? How can you make people not eat fructose or limit that for 50 years? Wouldnt call the article junk sciensce. We also need hypothesis builing articles. I think they are proposing a specific mechanism of action about how fructose might cause Alzheimers. I believe there are other clues also pointing in this direction, which I wont bore you with. Just want to note, that I think everyone would prefer high powered RCTs, but I dont believe they are feasible to fund and run