5 ms·

Someone with more domain knowledge, does this study hold water? Even perhaps as a reason to look further into the relationship between diet and Alzheimer’s?

Synaesthesia 4y ago
I watched an interesting presentation on YouTube about how fructose is digested in the body, its totally different to glucose, and arguably more harmful becuase the liver can only handle so much, there are various metabolic products which also need to be dealt with... So I do believe this may be very plausible.
- lab14 4y ago
  Would you mind sharing said YouTube presentation?
  - VLM 4y ago
    Probably "Sugar The Bitter Truth" by Lustig 2009 which was "controversial" at the time but more than a decade later its pretty much mainstream. You're always going to have members of the general public and docs who don't keep upon on continuing nutritional education (snark, there isn't any) saying stuff that was out of date decades ago but I'd say the stuff in that video is pretty much mainstream now.
    - Synaesthesia 4y ago
      That's the one.
- chasebank 4y ago
  "This leads to the overeating of high fat, sugary and salty food prompting excess fructose production." Perhaps I'm reading this wrong but the article suggests that it's not from digested fructose, rather the body is producing fructose. I'm confused.
  - abosley 4y ago
    Agreed....the part where it states that "Fructose produced in the brain could possibly lead to inflammation..." made me eye-roll...really hard.
    - unglaublich 4y ago
      Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight. 2017 Feb 23;2(4):e90508. doi: 10.1172/jci.insight.90508. PMID: 28239653; PMCID: PMC5313070. https://pubmed.ncbi.nlm.nih.gov/28239653/ https://pubmed.ncbi.nlm.nih.gov/28239653/
  - Py-o7 4y ago
    if you read Johnson's work, it's typically both. Direct fructose consumption as well as the polyol pathway being on and your body converting 'extra' glucose into fructose. excess fructose (in particular in ultra-processed forms) causes metabolic derangement but consuming too much of those other 3 esp from ultra processed foods, also activates the "switch" leading to endogenous fructose production and more derangement. The role of sedentarism in all this is somewhat under-explored though.
  - TeaBrain 4y ago
    Glucose can be converted to fructose in the body via the enzyme glucose-6-phosphate isomerase. https://en.m.wikipedia.org/wiki/Glucose-6-phosphate_isomerase https://en.m.wikipedia.org/wiki/Glucose-6-phosphate_isomeras...

Synaesthesia 4y ago

I watched an interesting presentation on YouTube about how fructose is digested in the body, its totally different to glucose, and arguably more harmful becuase the liver can only handle so much, there are various metabolic products which also need to be dealt with... So I do believe this may be very plausible.

lab14 4y ago
Would you mind sharing said YouTube presentation?
- VLM 4y ago
  Probably "Sugar The Bitter Truth" by Lustig 2009 which was "controversial" at the time but more than a decade later its pretty much mainstream. You're always going to have members of the general public and docs who don't keep upon on continuing nutritional education (snark, there isn't any) saying stuff that was out of date decades ago but I'd say the stuff in that video is pretty much mainstream now.
  - Synaesthesia 4y ago
    That's the one.
chasebank 4y ago
"This leads to the overeating of high fat, sugary and salty food prompting excess fructose production." Perhaps I'm reading this wrong but the article suggests that it's not from digested fructose, rather the body is producing fructose. I'm confused.
- abosley 4y ago
  Agreed....the part where it states that "Fructose produced in the brain could possibly lead to inflammation..." made me eye-roll...really hard.
  - unglaublich 4y ago
    Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight. 2017 Feb 23;2(4):e90508. doi: 10.1172/jci.insight.90508. PMID: 28239653; PMCID: PMC5313070. https://pubmed.ncbi.nlm.nih.gov/28239653/ https://pubmed.ncbi.nlm.nih.gov/28239653/
- Py-o7 4y ago
  if you read Johnson's work, it's typically both. Direct fructose consumption as well as the polyol pathway being on and your body converting 'extra' glucose into fructose. excess fructose (in particular in ultra-processed forms) causes metabolic derangement but consuming too much of those other 3 esp from ultra processed foods, also activates the "switch" leading to endogenous fructose production and more derangement. The role of sedentarism in all this is somewhat under-explored though.
- TeaBrain 4y ago
  Glucose can be converted to fructose in the body via the enzyme glucose-6-phosphate isomerase. https://en.m.wikipedia.org/wiki/Glucose-6-phosphate_isomerase https://en.m.wikipedia.org/wiki/Glucose-6-phosphate_isomeras...