3 ms·

Except... you still shouldn't use it because it's an anticolinergic linked to dementia in old age, just like Benedryl.

• EarthLaunch 4y ago
  Thank you, this led me down a really interesting rabbithole about age-related dementia and anticholinergic substances. Best tidbits: 1: "Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements" https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12437 https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12437 2: Chart of medicines with high ACB scores (higher is worse) - you will recognize some of these, such as allergy and anti-nausea meds: (pdf warning) https://corumpharmacy.com/wp-content/uploads/2020/08/Anticholinergic-cognitive-burden-scale.pdf https://corumpharmacy.com/wp-content/uploads/2020/08/Anticho...
  • avereveard 4y ago
    Ugh, imodium too.
    • EarthLaunch 4y ago
      Yes :( luckily it may be okay, being in the category “Possible anticholinergics include those listed with a score of 1”.
• refurb 4y ago
  So are most antihistamines. Everything will kill you, no need to get worked up about the infinitesimal risk.
  • RobotToaster 4y ago
    Most later generation ones can't cross the blood brain barrier.
    • refurb 4y ago
      They can cross the blood brain barrier, but just not as much. https://www.bmj.com/content/321/7260/572.1 https://www.bmj.com/content/321/7260/572.1 17% vs 77%