There have been efforts in the last decade to engineer yeast to produce lysergic acid (https://www.theguardian.com/science/blog/2011/jun/21/scientists-make-lsd-

There have been efforts in the last decade to engineer yeast to produce lysergic acid (https://www.theguardian.com/science/blog/2011/jun/21/scientists-make-lsd-from-microbes https://www.theguardian.com/science/blog/2011/jun/21/scienti...). Apparently, a group managed to introduce the complete pathway and published an article last year: https://www.nature.com/articles/s41467-022-28386-6 https://www.nature.com/articles/s41467-022-28386-6