I think they are overselling... Not clear to me how they treated the multiple testing across 22 tissues - gene expression measurements across different tissues

I think they are overselling... Not clear to me how they treated the multiple testing across 22 tissues - gene expression measurements across different tissues in a single mouse are clearly not independent from each other. > A total of 15,430 genes were DE in at least one tissue, but only 816 and 1,335 genes were differentially up- or downregulated, respectively, by TRF in ≥5 tissues