4 ms·
That summary is paywalled, but the paper it supposedly summarizes is open access. Available here: https://www.nature.com/articles/s43587-023-00361-w https://w
by A_D_E_P_T 4y ago
That summary is paywalled, but the paper it supposedly summarizes is open access. Available here: https://www.nature.com/articles/s43587-023-00361-w https://www.nature.com/articles/s43587-023-00361-w
Basically, the authors were able to treat progeria (to some extent) by designing a peptide which prevented progerin (the characteristic progeria protein) from binding with the ubiquitous cellular regulator protein BUBR1.
It has been known for about 20 years that BUBR1 irregularities can be associated with early-onset aging phenotypes: https://www.nature.com/articles/ng1382 https://www.nature.com/articles/ng1382