Like I said this isn't that surprising. In ethnobotany if a plant is medicinally important across many cultures like this it's usually a sure bet that there's a

Like I said this isn't that surprising. In ethnobotany if a plant is medicinally important across many cultures like this it's usually a sure bet that there's a ton of interesting secondary metabolites with interesting properties being produced by that plant. These "highly medicinal plants" are actually quite common Some other examples of highly medicinal plants from PFAF: Ammi visnaga[^0] Visnaga is an effective muscle relaxant and has been used for centuries to alleviate the excruciating pain of kidney stones[254]. Modern research has confirmed the validity of this traditional use[254]. Visnagin contains khellin, from which particularly safe pharmaceutical drugs for the treatment of asthma have been made[254]. The seeds are diuretic and lithontripic[46]. They contain a fatty oil that includes the substance 'khellin'. This has been shown to be of benefit in the treatment of asthma[238]. Taken internally, the seeds have a strongly antispasmodic action on the smaller bronchial muscles[254], they also dilate the bronchial, urinary and blood vessels without affecting blood pressure[238]. The affect last for about 6 hours and the plant has practically no side effects[254]. The seeds are used in the treatment of asthma, angina, coronary arteriosclerosis and kidney stones[238]. By relaxing the muscles of the urethra, visnaga reduces the pain caused by trapped kidney stones and helps ease the stone down into the bladder[254]. The seeds are harvested in late summer before they have fully ripened and are dried for later use[254]. Cinchona pubescens[^1] Red bark has a long history of native use, especially as a treatment for fevers and malaria. Modern research has shown it to be a very effective treatment for fevers, and especially as a treatment and preventative of malaria. The bark contains various alkaloids, particularly quinine and quinidine. Up to 70 - 80% of the total alkaloids contained in the bark are quinine[ 418 ]. The bark is a bitter, astringent, tonic herb that lowers fevers, relaxes spasms, is antimalarial (the alkaloid quinine) and slows the heart (the alkaloid quinidine)[ 238 ]. The bark is made into various preparations, such as tablets, liquid extracts, tinctures and powders[ 238 ]. It is used internally in the treatment of malaria, neuralgia, muscle cramps and cardiac fibrillation[ 238 ]. It is an ingredient in various proprietary cold and influenza remedies[ 238 ]. The liquid extract is useful as a cure for drunkenness[ 418 ]. It is also used as a gargle to treat sore throats[ 238 ]. Care must be taken in the use of this herb since excess can cause a number of side effects including cinchonism, headache, rash, abdominal pain, deafness and blindness[ 238 ]. The herb, especially in the form of the extracted alkaloid quinine, is subject to legal restrictions in some countries[ 238 ]. Hamamelis virginiana[^2] Witch hazel bark is a traditional herb of the North American Indians who used it to heal wounds, treat tumours, eye problems etc[254]. A very astringent herb, it is commonly used in the West and is widely available from both herbalists and chemists[222]. It is an important ingredient of proprietary eye drops, skin creams, ointments and skin tonics[238]. It is widely used as an external application to bruises, sore muscles, varicose veins, haemorrhoids, sore nipples, inflammations etc[238]. The bark is astringent, haemostatic, sedative and tonic[4, 14, 21, 165, 171, 222]. Tannins in the bark are believed to be responsible for its astringent and haemostatic properties[222]. Bottled witch hazel water is a steam distillate that does not contain the tannins from the shrub[222], this is less effective in its action than a tincture[238]. The bark is used internally in the treatment of diarrhoea, colitis, dysentery, haemorrhoids, vaginal discharge, excessive menstruation, internal bleeding and prolapsed organs[238]. Branches and twigs are harvested for the bark in the spring[238]. An infusion of the leaves is used to reduce inflammations, treat piles, internal haemorrhages and eye inflammations[213]. The leaves are harvested in the summer and can be dried for later use[238]. A homeopathic remedy is made from fresh bark[232]. It is used in the treatment of nosebleeds, piles and varicose veins[232]. Pueraria montana[^3] The kudzu vine, known as Ge Gen in China, is commonly used in Chinese herbalism, where it is considered to be one of the 50 fundamental herbs[218 ]. Recent research has shown that compounds called 'daidzin' and 'daidzein', which are contained in the roots and the flowers, are a safe and effective method for treating alcohol abuse[238 ]. They work by suppressing the appetite for alcohol, whereas existing treatments interfere with the way the alcohol is metabolised and can cause a build-up of toxins[238 ]. The plant is often used in combination with Chrysanthemum x morifolium in treating alcohol abuse[254 ]. The flowers and the roots are antidote, antiemetic, antipyretic, antispasmodic, demulcent, diaphoretic, digestive, febrifuge, hypoglycaemic and hypotensive[174 , 176 , 218 , 222 , 238 ]. A concoction of the flowers and tubers is used to treat alcoholism, fever, colds, diarrhoea, dysentery, acute intestinal obstruction etc[174 , 176 , 218 , 222 ]. It is useful in the treatment of angina pectoris and migraine[218 ]. The root is frequently used as a remedy for measles, often in combination with Cimicifuga foetida[254 ]. The root contains puerarin. This increases the blood flow to the coronary artery and protects against acute myocardial ischaemia caused by the injection of pituitrin[176 ]. The root can be harvested from the autumn to the spring and is used fresh or dried[238 ]. The flowers are harvested just before they are fully open and are dried for later use[238 ]. The stems are galactagogue and are also applied as a poultice to incipient boils, swellings, sore mouths etc[218 , 222 ]. The seed is used in the treatment of hangover and dysentery[218 , 222 ]. The leaves are styptic[218 ]. Ethnobotany is still the main source of new drug discoveries. Culturally medicinal plants like these are easy to identify and then it's just a matter of isolating the active ingredients and investigating ways to manufacture it or increase its effects. We often think of drugs as being single dimensional or serving a single use-case but I think this is mostly a product of how the modern scientific and legal process works and how much work it takes to approve a drug for a particular use-case. [^0]: https://pfaf.org/user/Plant.aspx?LatinName=Ammi+visnaga https://pfaf.org/user/Plant.aspx?LatinName=Ammi+visnaga [^1]: https://pfaf.org/user/Plant.aspx?LatinName=Cinchona+pubescens https://pfaf.org/user/Plant.aspx?LatinName=Cinchona+pubescen... [^2]: https://pfaf.org/user/Plant.aspx?LatinName=Hamamelis+virginiana https://pfaf.org/user/Plant.aspx?LatinName=Hamamelis+virgini... [^3]: https://pfaf.org/user/Plant.aspx?LatinName=Pueraria+montana https://pfaf.org/user/Plant.aspx?LatinName=Pueraria+montana