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You are confusing PDE5 and PDE4 inhibitors. PDE5 inhibitors are popular erectile dysfunction drugs and work via nitric oxide. PDE4 inhibitors are anti-inflamm
by narrator 4y ago
You are confusing PDE5 and PDE4 inhibitors. PDE5 inhibitors are popular erectile dysfunction drugs and work via nitric oxide. PDE4 inhibitors are anti-inflammatory in the lungs and also have cognitive enhancing effects by potentiation of cAMP secondary messenger systems that trigger LTP encoding in neurons.
Nitric oxide is not involved in the action of PDE4.
- FollowingTheDao 4y ago> You are confusing PDE5 and PDE4 inhibitors Yes, sorry for the oversight. > Nitric oxide is not involved in the action of PDE4. ? Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission https://www.nature.com/articles/s41598-018-22934-1 https://www.nature.com/articles/s41598-018-22934-1 cAMP Phosphodiesterase Inhibitors Increases Nitric Oxide Production by Modulating Dimethylarginine Dimethylaminohydrolases https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.941484 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.9... PDE4 inhibitors are most likely anti-inflammatory because they affect NO.
- narrator 4y agoNitric oxide effects are downstream from cAMP which is degraded by PDE4. cAMP increases usually come from g-protein coupled receptors releasing it and then there's a cascade that depending on the cell type may create Nitric oxide. However, nitric oxide is upstream of cGMP metabolically and is degraded by PDE5. https://www.reading.ac.uk/nitricoxide/intro/no/cgmp.htm https://www.reading.ac.uk/nitricoxide/intro/no/cgmp.htm