4 ms·

That sounds like a catastrophically bad idea.

mikeyouse 4y ago
It was 2020 when the drug was undergoing development.. literally throw everything at the wall and try to stave off the mass death from uncontrolled spread. Fortunately other therapeutics worked as well, the vaccines were developed quickly and had very high efficacy, and subsequent strains of Covid mostly became more mild (this wasn't a guarantee, regardless of how insistent people may be). The drug works, it reduces hospitalization and mortality in people who take it, but we don't actually need it for the most part so these studies are just further confirmation of that.
- strbean 4y ago
  The study linked in another comment finds that it doesn't reduce hospitalization or mortality: https://www.bmj.com/content/379/bmj.o3055 https://www.bmj.com/content/379/bmj.o3055 And while I understand the "see what sticks" mentality, drastically increasing the mutation rate of the virus responsible for a global pandemic... seems to me like it's on the order of "maybe we start dropping nukes, that'll slow the spread".
  - mikeyouse 4y ago
    It doesn't in vaccinated people - but it did in unvaccinated people. There was no guarantee that we'd develop a vaccine in any reasonable amount of time, and reducing deaths and the overburdening of our limited health care resources was the #1 goal in 2020.
pueblito 4y ago
After the recent Project Veritas videos on Directed Evolution, it seems like that’s the actual goal
GuB-42 4y ago
Doesn't seem that bad to me, the virus doesn't need Molnupiravir to mutate. It can do very well by itself, in the billion people and animals it infected. The fact we are seeing convergent evolution shows that it is naturally very good at this. By increasing the mutation rate way beyond the sweet spot (that what's Molnupiravir does) the virus may get some desirable mutations, but won't be able to hold on to them. And if, thanks to the drug, the patient is cured, it is bad news for the virus, those who are not infected can't produce new variants. But like antibiotics, I think this is an "all or nothing" drug. Either give maximum dose to do as much damage as possible, or don't give anything at all. Too small a dose may promote building resistance instead.
PaulDavisThe1st 4y ago
TFA is about why it is not obviously a catastrophically bad idea.

It was 2020 when the drug was undergoing development.. literally throw everything at the wall and try to stave off the mass death from uncontrolled spread. Fortunately other therapeutics worked as well, the vaccines were developed quickly and had very high efficacy, and subsequent strains of Covid mostly became more mild (this wasn't a guarantee, regardless of how insistent people may be). The drug works, it reduces hospitalization and mortality in people who take it, but we don't actually need it for the most part so these studies are just further confirmation of that.

strbean 4y ago
The study linked in another comment finds that it doesn't reduce hospitalization or mortality: https://www.bmj.com/content/379/bmj.o3055 https://www.bmj.com/content/379/bmj.o3055 And while I understand the "see what sticks" mentality, drastically increasing the mutation rate of the virus responsible for a global pandemic... seems to me like it's on the order of "maybe we start dropping nukes, that'll slow the spread".
- mikeyouse 4y ago
  It doesn't in vaccinated people - but it did in unvaccinated people. There was no guarantee that we'd develop a vaccine in any reasonable amount of time, and reducing deaths and the overburdening of our limited health care resources was the #1 goal in 2020.

pueblito 4y ago

After the recent Project Veritas videos on Directed Evolution, it seems like that’s the actual goal

GuB-42 4y ago

Doesn't seem that bad to me, the virus doesn't need Molnupiravir to mutate. It can do very well by itself, in the billion people and animals it infected. The fact we are seeing convergent evolution shows that it is naturally very good at this. By increasing the mutation rate way beyond the sweet spot (that what's Molnupiravir does) the virus may get some desirable mutations, but won't be able to hold on to them. And if, thanks to the drug, the patient is cured, it is bad news for the virus, those who are not infected can't produce new variants. But like antibiotics, I think this is an "all or nothing" drug. Either give maximum dose to do as much damage as possible, or don't give anything at all. Too small a dose may promote building resistance instead.

PaulDavisThe1st 4y ago

TFA is about why it is not obviously a catastrophically bad idea.