3 ms·
[Tangent warning] I recall some scare awhile back about a possible link between diphenhydramine and dementia / Alzheimer's. Googling turns up a study from 2008
by strbean 4y ago
[Tangent warning]
I recall some scare awhile back about a possible link between diphenhydramine and dementia / Alzheimer's. Googling turns up a study from 2008. Anyone know if that held water, or if there is ongoing research into that link?
I've generally avoided the drug since hearing about that, but I used it much in the first place.
- dangoor 4y agoThis has references newer than 2008: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Diphenhydramine-Cognitive-Vitality-For-Researchers.pdf https://www.alzdiscovery.org/uploads/cognitive_vitality_medi... At the top, it talks about "long term use", so it may be okay under acute circumstances.
- Baeocystin 4y agoAnticholinergics are associated with an increase of risk of dementia, and diphenhydramine is a pretty strong one, considering its OTC nature. I still use it occasionally myself, but I agree that it's a good idea not to take on a regular basis. Here's a paper from 2019 that covers this: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2736353 https://jamanetwork.com/journals/jamainternalmedicine/fullar...