2 ms·
I recall hearing something about selective targeting with CRISPR gene editing packages to target latent cells containing the viral sequence. This might be it:
by photochemsyn 4y ago
I recall hearing something about selective targeting with CRISPR gene editing packages to target latent cells containing the viral sequence. This might be it:
https://www.nature.com/articles/s41598-019-40222-4 https://www.nature.com/articles/s41598-019-40222-4
> (2016) Kaushik et al. "Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection"
> "In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulation (NF), composed of Cas9/gRNA bound with magneto-electric nanoparticles (MENPs), across the blood-brain barrier (BBB) to inhibit latent HIV-1 infection in microglial (hμglia)/HIV (HC69) cells. An optimized ac-magnetic field of 60 Oe was applied on NF to release Cas9/gRNA from MENPs surface and to facilitate NF cell uptake resulting in intracellular release and inhibition of HIV."
Seems promising, I suppose complete clearance might still be difficult.