Depends on what you mean by "tolerable". Oral antibiotics leave you on the toilet because they go to the gut. The method of action doesn't change the systemic a

Depends on what you mean by "tolerable". Oral antibiotics leave you on the toilet because they go to the gut. The method of action doesn't change the systemic affects though. If anything, oral antibiotics are more tolerated by the body because half of them are eaten by stomach acid. With an IV, you're putting your kidneys to work.