5 ms·

check: glyphosate gut-brain axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+ax...

by pella 4y ago

ch4s3 4y ago
The important caveat here is in laboratory mice, which isn't to dismiss ongoing work but to temper strong claims a bit.
- pella 4y ago
  but enough to refute this type of claim: "... glyphosate has been considered to be generally safe to animal health .."
  - ch4s3 4y ago
    Does it? You can harm those deeply inbreed and sickly lab mice with almost anything, and these types of results often don't generalize to animals outside of the lab setting. The few I skimmed don't indicate dose, generalize out form some tentative stuff from past studies, and some are making wild claims about things like autism which seem to be out of line with meta-analysis[1] of the links between dysbiotic bacteria with respect to ASD. And this analysis points to the effects only being on rat pups[2] where it was administered in drinking water. And digging a little further it seems that the evidence on actual levels in food being dangerous to humans or other mammals is lacking[3] so I don't think it refutes the claim at all. [1] https://link.springer.com/article/10.1007/s10803-021-05002-y https://link.springer.com/article/10.1007/s10803-021-05002-y [2] https://link.springer.com/article/10.1186/s12940-018-0394-x https://link.springer.com/article/10.1186/s12940-018-0394-x [3] https://www.sciencedirect.com/science/article/abs/pii/S0013935122012609 https://www.sciencedirect.com/science/article/abs/pii/S00139...
pella 4y ago
"Gut microbiota and neurological effects of glyphosate" ( 2019, NeuroToxicology ) "Abstract There are currently various concerns regarding certain environmental toxins and the possible impact they can have on developmental diseases. Glyphosate (Gly) is the most utilised herbicide in agriculture, although its widespread use is generating controversy in the scientific world because of its probable carcinogenic effect on human cells. Gly performs as an inhibitor of 5-enolpyruvylshikimate-3-phospate synthase (EPSP synthase), not only in plants, but also in bacteria. An inhibiting effect on EPSP synthase from intestinal microbiota has been reported, affecting mainly beneficial bacteria. To the contrary, Clostridium spp. and Salmonella strains are shown to be resistant to Gly. Consequently, researchers have suggested that Gly can cause dysbiosis, a phenomenon which is characterised by an imbalance between beneficial and pathogenic microorganisms. The overgrowth of bacteria such as clostridia generates high levels of noxious metabolites in the brain, which can contribute to the development of neurological deviations. This work reviews the impact of Gly-induced intestinal dysbiosis on the central nervous system, focusing on emotional, neurological and neurodegenerative disorders. A wide variety of factors were investigated in relation to brain-related changes, including highlighting genetic abnormalities, pregnancy-associated problems, diet, infections, vaccines and heavy metals. However, more studies are required to determine the implication of the most internationally used herbicide, Gly, in behavioural disorders." read more: https://www.sciencedirect.com/science/article/abs/pii/S0161813X19300816 https://www.sciencedirect.com/science/article/abs/pii/S01618...

check: glyphosate gut-brain axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+ax...

by pella 4y ago

check: glyphosate gut-brain axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+axis https://scholar.google.com/scholar?q=glyphosate+gut-brain+ax...

ch4s3 4y ago

The important caveat here is in laboratory mice, which isn't to dismiss ongoing work but to temper strong claims a bit.

pella 4y ago
but enough to refute this type of claim: "... glyphosate has been considered to be generally safe to animal health .."
- ch4s3 4y ago
  Does it? You can harm those deeply inbreed and sickly lab mice with almost anything, and these types of results often don't generalize to animals outside of the lab setting. The few I skimmed don't indicate dose, generalize out form some tentative stuff from past studies, and some are making wild claims about things like autism which seem to be out of line with meta-analysis[1] of the links between dysbiotic bacteria with respect to ASD. And this analysis points to the effects only being on rat pups[2] where it was administered in drinking water. And digging a little further it seems that the evidence on actual levels in food being dangerous to humans or other mammals is lacking[3] so I don't think it refutes the claim at all. [1] https://link.springer.com/article/10.1007/s10803-021-05002-y https://link.springer.com/article/10.1007/s10803-021-05002-y [2] https://link.springer.com/article/10.1186/s12940-018-0394-x https://link.springer.com/article/10.1186/s12940-018-0394-x [3] https://www.sciencedirect.com/science/article/abs/pii/S0013935122012609 https://www.sciencedirect.com/science/article/abs/pii/S00139...

pella 4y ago

"Gut microbiota and neurological effects of glyphosate" ( 2019, NeuroToxicology ) "Abstract There are currently various concerns regarding certain environmental toxins and the possible impact they can have on developmental diseases. Glyphosate (Gly) is the most utilised herbicide in agriculture, although its widespread use is generating controversy in the scientific world because of its probable carcinogenic effect on human cells. Gly performs as an inhibitor of 5-enolpyruvylshikimate-3-phospate synthase (EPSP synthase), not only in plants, but also in bacteria. An inhibiting effect on EPSP synthase from intestinal microbiota has been reported, affecting mainly beneficial bacteria. To the contrary, Clostridium spp. and Salmonella strains are shown to be resistant to Gly. Consequently, researchers have suggested that Gly can cause dysbiosis, a phenomenon which is characterised by an imbalance between beneficial and pathogenic microorganisms. The overgrowth of bacteria such as clostridia generates high levels of noxious metabolites in the brain, which can contribute to the development of neurological deviations. This work reviews the impact of Gly-induced intestinal dysbiosis on the central nervous system, focusing on emotional, neurological and neurodegenerative disorders. A wide variety of factors were investigated in relation to brain-related changes, including highlighting genetic abnormalities, pregnancy-associated problems, diet, infections, vaccines and heavy metals. However, more studies are required to determine the implication of the most internationally used herbicide, Gly, in behavioural disorders." read more: https://www.sciencedirect.com/science/article/abs/pii/S0161813X19300816 https://www.sciencedirect.com/science/article/abs/pii/S01618...