I disagree with the conclusion that the person probably would not be eligible for unemployment benefits if they quit. I used to adjudicate unemployment claims,

I disagree with the conclusion that the person probably would not be eligible for unemployment benefits if they quit. I used to adjudicate unemployment claims, and a significant change in working conditions is considered a valid reason to quit, as long as you don't, like, go along with it for a year and then decide it's untenable. If you quit once the change is actually required, especially if you have documentation saying the role you agreed to definitely had the condition of being permanently remote, you can still receive benefits even though you quit. The documentation about the anxiety and/or OCD would also help. It establishes, "See? I'm doing my best to work and not depend on the government, and I thought I had found a job I could actually do, but then they changed it and now I can't anymore."