Well just for a contrasting data point: at the small SV startup I work for, I don't know of anybody who uses "performance enhancing" drugs [aside from caffeine,

Well just for a contrasting data point: at the small SV startup I work for, I don't know of anybody who uses "performance enhancing" drugs [aside from caffeine, but in that case the majority of the working world would qualify] and I would heartily discourage anybody from sacrificing their health for job performance. I'm not saying it doesn't sound potentially plausible, but this is the first time I have heard of it so it certainly isn't something that everybody does.