Honestly, not that big of a deal, switching between layouts. At some point I switched between DE and US-International where basically all of the characters used

Honestly, not that big of a deal, switching between layouts. At some point I switched between DE and US-International where basically all of the characters used for programming are in different places. I still can go back and forth between them. I know people who have tried a bunch of different layouts, and maybe the best comparison is “swimming styles”. The people who tried like more than two, had no problem switching back and forth. If you are a professional swimmer, you will have no trouble switching between styles. For vim and Dvorak specifically there seem to be macros which map Dvorak to QWERTY under the hood if not in edit mode. So you can use muscle memory for that.