5 ms·
As someone who has used opiates for well over a decade (for medical reasons), heroin and stronger synthetic opioids can absolutely cause an opioid naive individ
by atdrummond 4y ago
As someone who has used opiates for well over a decade (for medical reasons), heroin and stronger synthetic opioids can absolutely cause an opioid naive individual to have withdrawal symptoms after even a week.
This is why codeine OTC recommends no more than three consecutive days of use.
- mise_en_place 4y agoIt depends on if you have a specific antibody that targets specific opiate compounds. For example, oxycodone was very dysphoric and caused me even more pain, whereas hydrocodone caused me the intended therapeutic effect of euphoria and analgesia
- cellis 4y agoHydrocodone has to be one of the best drugs known to man. I had a very small prescription for my wisdom teeth and I instantly understood the opioid dependency problem.
- devilbunny 4y agoIt's all about your body chemistry. I'm a redhead; red hair is a result of a mutation in the preopiomelanocortin (POMC) system, so opioids work funny on us. I've had hydrocodone/acetaminophen(paracetamol) pills, and they felt like... taking acetaminophen. No euphoria, not even increased pain relief. I quit after one dose, because what was the point in making myself constipated?
- Nihilartikel 4y agoI dunno man. My mom and dad were both smack heads. They both went through recovery but had substantial relapses. My mom was as ginger as they come but really couldn't get off the horse. Dad found solace in terminal alcoholism. So.. I dunno. Thoughts?
- devilbunny 4y agoBooze doesn't work that way, and there are a lot of mutations that can cause gingerism - but the one I have, opioids don't do much of anything. Never had the hard stuff and not inclined to try. But the oral ones might as well be cornstarch.
- grafporno 4y agoWait, you've got over-the-counter opiates in the US (I assume it's the US)? What?
- rejectfinite 4y agoThe UK has codeine OTC... you assume. Everyone on the internet is american. Its funny. ahha
- nwiswell 4y agoNot that unreasonable a guess. It's very late in Europe right now (currently 4 AM GMT, perhaps 2 AM when that was posted), and you know YC is an American company... right? https://news.ycombinator.com/item?id=30210378 https://news.ycombinator.com/item?id=30210378
- benj111 4y agoWhy is the ownership structure of YC important? You know how the internet works right? For better or worse, 'american' is the defacto standard on the internet, but please remember that only a small percentage of the global population is USian the in all probability the person you're speaking to isn't from the US.
- hnfong 4y agoThe English (no pun intended) speaking population is more likely to be from the US than the global population. Disclaimer: Not English. Not American.
- benj111 4y agoI would say that the us accounts for less than half of English speaking netizens. UK, Australia, new zealand Canada already add up to a sizeable chunk of the US's population. Then add in 1% of India, or China (I assume some proportion has access outside the great firewall) and you've got a population bigger than the US.
- refurb 4y agoThat’s true, but the withdrawal after a week or two isnt going to be the “i just want to die” type. Severe withdrawal comes after dose escaation and youre not going to develop that much tolerance after 2 weeks. Im not saying it wouldnt be unpleasant, but its not goibg to be the Trainspotting version.