The full study mentions that other studies found nasal snuff produced the highest plasma nicotine concentration at 0.8 uM, with speculation that a large (emphas

The full study mentions that other studies found nasal snuff produced the highest plasma nicotine concentration at 0.8 uM, with speculation that a large (emphasis mine) pinch would produce mM concentrations in the nasal cavity, right on target for observed DNA damage, yet incidents of nasal cancer among western nasal snuff users are practically unheard of. Similarly, rates of oral cancer among Swedish Snus users are so low that several studies now have failed to find any association with oral cancer. This says nothing about rates of other non-site specific cancers of course (pancreatic being a big one), or the other health risks that are still associated with smokeless tobacco (stroke, cardiovascular disease, impotency), but it's somewhat telling that even anti-nicotine advocacy groups rarely mention the risk of cancer for smokeless tobacco products in their publications.