Most drugs are dose dependent. The effects of nicotine as an anxiolytic are well known: https://pubmed.ncbi.nlm.nih.gov/12151749/ https://pubmed.ncbi.nlm.nih.

Most drugs are dose dependent. The effects of nicotine as an anxiolytic are well known: https://pubmed.ncbi.nlm.nih.gov/12151749/ https://pubmed.ncbi.nlm.nih.gov/12151749/ Rat studies to find dose limits are a valid case for rat studies.