4 ms·
Depends on the population, it means that they increase the number of drug resistant mutants. Since it only affects people who would take molnupiravir which are
by kurthr 4y ago
Depends on the population, it means that they increase the number of drug resistant mutants. Since it only affects people who would take molnupiravir which are then exposed to the mutant anyway (likely in hospitals and rest homes?) the alternative is no treatment. However, in these patients the no treatment alternative is likely to lead to much longer infections with more mutations and chances for transmission.
If those people were well isolated when they were taking the drug then the mutants wouldn't be transmitted. If the hospitals and homes are well isolated then the mutants won't be transmitted. There is in any case a wide reservoir of virus and mutants in the broader population and it isn't clear that in that broader population that this resistance makes the virus fitter (more likely to be transmitted) and it's likely they are less fit.
The really infective versions seem to have come from immune compromised patients who were infected and likely infectious (not just sick like long covid) for months.