4 ms·

Stanford researchers measure thousands of molecules from a single drop of blood

7 points by panabee 4y ago

panabee 4y ago
Paper URL (free) https://www.nature.com/articles/s41551-022-00999-8 https://www.nature.com/articles/s41551-022-00999-8 Abstract Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by geographical barriers, the cost and inconvenience of in-clinic venepuncture, low sampling frequency and the low depth of molecular measurements. Here we describe a strategy for the frequent capture and analysis of thousands of metabolites, lipids, cytokines and proteins in 10 μl of blood alongside physiological information from wearable sensors. We show the advantages of such frequent and dense multi-omics microsampling in two applications: the assessment of the reactions to a complex mixture of dietary interventions, to discover individualized inflammatory and metabolic responses; and deep individualized profiling, to reveal large-scale molecular fluctuations as well as thousands of molecular relationships associated with intra-day physiological variations (in heart rate, for example) and with the levels of clinical biomarkers (specifically, glucose and cortisol) and of physical activity. Combining wearables and multi-omics microsampling for frequent and scalable omics may facilitate dynamic health profiling and biomarker discovery.
eabrams 4y ago
I think we know how this ends already, no?
- pmdulaney 4y ago
  You're talking about Elizabeth Holmes, right? The idea was always a good one...
- richardatlarge 4y ago
  Lest we not forget, there be a sucker born every minute
- fsociety 4y ago
  The difference is… these researchers are taking on work in an attempt to make the idea reality. Whereas Theranos pretended they had a working product to convince investors to give them money and to convince companies to buy their “product”.
deleted 4y ago
[deleted]
Justin_K 4y ago
I swear I've heard this story before....

7 points by panabee 4y ago

Paper URL (free) https://www.nature.com/articles/s41551-022-00999-8 https://www.nature.com/articles/s41551-022-00999-8 Abstract Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by geographical barriers, the cost and inconvenience of in-clinic venepuncture, low sampling frequency and the low depth of molecular measurements. Here we describe a strategy for the frequent capture and analysis of thousands of metabolites, lipids, cytokines and proteins in 10 μl of blood alongside physiological information from wearable sensors. We show the advantages of such frequent and dense multi-omics microsampling in two applications: the assessment of the reactions to a complex mixture of dietary interventions, to discover individualized inflammatory and metabolic responses; and deep individualized profiling, to reveal large-scale molecular fluctuations as well as thousands of molecular relationships associated with intra-day physiological variations (in heart rate, for example) and with the levels of clinical biomarkers (specifically, glucose and cortisol) and of physical activity. Combining wearables and multi-omics microsampling for frequent and scalable omics may facilitate dynamic health profiling and biomarker discovery.

eabrams 4y ago

I think we know how this ends already, no?

pmdulaney 4y ago
You're talking about Elizabeth Holmes, right? The idea was always a good one...
richardatlarge 4y ago
Lest we not forget, there be a sucker born every minute
fsociety 4y ago
The difference is… these researchers are taking on work in an attempt to make the idea reality. Whereas Theranos pretended they had a working product to convince investors to give them money and to convince companies to buy their “product”.

deleted 4y ago

[deleted]

Justin_K 4y ago

I swear I've heard this story before....