I might be wrong, but I believe that Mypyc is like Nuitka in that you're still using an interpreter that will end up being your bottleneck even after compiling

I might be wrong, but I believe that Mypyc is like Nuitka in that you're still using an interpreter that will end up being your bottleneck even after compiling your code. Nuitka gives a ~4x speedup for most code, the bottleneck being the Python VM. You might want to reach for something else if you need better performance than that.