Depression seems like dementia/Alzheimer's: not a single disease but a process with holistic factors. Interestingly, I'm convinced depressive state accumulates

Depression seems like dementia/Alzheimer's: not a single disease but a process with holistic factors. Interestingly, I'm convinced depressive state accumulates during a sleep cycle. Missing a single dose of mirtazapine and then sleeping feels exactly like an alcohol hangover. I'm also convinced alcohol is a CNS depressant and abuse of it induces depression. Edit: Similar experience. Chaotic home life with fighting parents with high anxiety levels. Emotional problems, speech issues, out-of-norm appearance and intellect, bullying, and intense untreated depression and ADHD-PI for many years. Too many factors to control for. I suspect genes and epigenetics.