SSRI efficacy is already in doubt, as roughly 80% of the beneficial effects are replicated by placebos; some research has suggested that the remaining differenc

SSRI efficacy is already in doubt, as roughly 80% of the beneficial effects are replicated by placebos; some research has suggested that the remaining difference is due to the side effects, which make SSRIs active placebos and mess with study blinding. And, even if they are better than just an active placebo, the mechanism is probably not the effects on serotonin levels. (Discussed previously here: https://news.ycombinator.com/item?id=32160703 https://news.ycombinator.com/item?id=32160703)