5 ms·
That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content
by lr4444lr 4y ago
That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content in cohorts who are subjectively feeling improved by SSRIs.
- andy_ppp 4y agoIt would also explain why SSRIs take time to work - as I understand it the SSRI action is immediate and yet it takes weeks for people to notice the effects.
- kayodelycaon 4y agoSSRIs aren’t the only medication that requires weeks to work.
- NickM 4y agoSSRI efficacy is already in doubt, as roughly 80% of the beneficial effects are replicated by placebos; some research has suggested that the remaining difference is due to the side effects, which make SSRIs active placebos and mess with study blinding. And, even if they are better than just an active placebo, the mechanism is probably not the effects on serotonin levels. (Discussed previously here: https://news.ycombinator.com/item?id=32160703 https://news.ycombinator.com/item?id=32160703)
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