There's also the Bone-Brain-Gut connection and Bone Gut connection. Bones are complex structures made of various proteins and studies have shown some microbiome

There's also the Bone-Brain-Gut connection and Bone Gut connection. Bones are complex structures made of various proteins and studies have shown some microbiome as harmful to Bones or lack of diversity. There was an experiment in mice that showed some mice devoid of any gut bacteria had better bone density than the other experiment group. This is interesting and might suggest some bacteria can cause bone issues.