4 ms·

Wait - do I not know what the word 'vaccine' means?

by JackFr 4y ago

bobleeswagger 4y ago
[flagged]
- cantSpellSober 4y ago
  The COVID vaccine was designed to reduce the spread of an infectious disease, seems to fit the definition. Is there a different vaccine you refer to?
  - porkbeer 4y ago
    It used to mean something that actually gave you immunity to something. Like Polio.
    - cantSpellSober 4y ago
      No, I think it still meant something that reduces the spread infectious diseases. Like the COVID and Flu vaccines, the Polio vaccine does not provide 100% immunity to 100% of recipients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974751/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974751/
      - Izkata 4y ago
        > something that reduces the spread infectious diseases. Like the COVID That one doesn't do that though.
        cantSpellSober 4y ago
        don't forget the microchips amirite?!
    - ceejayoz 4y ago
      No, it didn't. That's "sterilizing immunity", which is a feature of some but not all vaccines. Flu shots, for example, have never given full immunity to the flu, but they've always been vaccines. In fact, some forms of the polio vaccine can give you polio. https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-poliovirus-faq.html https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-p...
      - Izkata 4y ago
        Those can give people around you polio while you remain immune.
        ceejayoz 4y ago
        If you're shedding active virus, you're infected with polio, even if it's an asymptomatic infection.
  - bobleeswagger 4y ago
    The COVID vaccine was designed to make an astronomical amount of money in a time of extreme inflation. If it made society better by "preventing infectious disease" that was a side-effect.
cantSpellSober 4y ago
Opioid addiction is a malignant disease, what's wrong with the usage here?
- CoastalCoder 4y ago
  We usually think of vaccines as medicines that train the immune system to attack unwelcome molecules / microbes. Perhaps the parent was asking if this technique actually uses the immune system? (From skimming the article, I think the answer is yes.)
  - cantSpellSober 4y ago
    In the 8th sentence it says the vaccine will "generate anti-fentanyl antibodies" with the goal of preventing mental illness.
neuronexmachina 4y ago
The study's intro explains the use of the term: https://www.mdpi.com/1999-4923/14/11/2290/htm https://www.mdpi.com/1999-4923/14/11/2290/htm > OUD [Opioid Use Disorder] is a chronic disorder that even with maintenance therapy has relapse rates approaching 90% largely due to poor medication compliance with current agents [17,18]. Immunotherapy using vaccines can reduce this compliance problem by requiring less frequent administration. Vaccine immunotherapy targets small molecule antigens such as opioid compounds consisting of the antigen (hapten) linked to an immunogenic carrier protein that stimulates the immune system to generate antibodies. An adjuvant is often added to the formulation to increase immunogenicity (antibody formation) against the hapten. After vaccination, when an opioid is consumed, antibodies bind to the target opioid in the periphery and prevent it from getting into the brain or affecting other organs. The kidneys subsequently eliminate bound drug from the body. Numerous pre-clinical studies targeting a broad range of opioids have demonstrated vaccine efficacy [16,19,20,21,22]. > Recent studies testing various formulations of anti-FEN vaccines show efficacy in attenuating the behavioral and lethal effects of FEN and its derivatives [23,24,25] including findings from our group [26]. Our vaccine formulation is composed of a FEN-like hapten containing a linker with a carboxyl moiety suitable for carbodiimide coupling chemistry to form amide bonds to lysine residues on the carrier protein CRM197, a genetically deactivated diphtheria toxin contained in several FDA-approved conjugate vaccines. We combined our conjugate (FEN-CRM) with an adjuvant derived from heat-labile enterotoxins from E. coli (LT) named dmLT or LT(R192G/L211A) that has been combined with other vaccines in several human clinical trials
orblivion 4y ago
I thought it seemed like a stretch to use that word, but from the article it sounds like the immune system literally attacks the fentanyl as if it's a pathogen.

Wait - do I not know what the word 'vaccine' means?

by JackFr 4y ago

Wait - do I not know what the word 'vaccine' means?

bobleeswagger 4y ago

[flagged]

cantSpellSober 4y ago
The COVID vaccine was designed to reduce the spread of an infectious disease, seems to fit the definition. Is there a different vaccine you refer to?
- porkbeer 4y ago
  It used to mean something that actually gave you immunity to something. Like Polio.
  - cantSpellSober 4y ago
    No, I think it still meant something that reduces the spread infectious diseases. Like the COVID and Flu vaccines, the Polio vaccine does not provide 100% immunity to 100% of recipients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974751/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974751/
    - Izkata 4y ago
      > something that reduces the spread infectious diseases. Like the COVID That one doesn't do that though.
      - cantSpellSober 4y ago
        don't forget the microchips amirite?!
  - ceejayoz 4y ago
    No, it didn't. That's "sterilizing immunity", which is a feature of some but not all vaccines. Flu shots, for example, have never given full immunity to the flu, but they've always been vaccines. In fact, some forms of the polio vaccine can give you polio. https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-poliovirus-faq.html https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-p...
    - Izkata 4y ago
      Those can give people around you polio while you remain immune.
      - ceejayoz 4y ago
        If you're shedding active virus, you're infected with polio, even if it's an asymptomatic infection.
- bobleeswagger 4y ago
  The COVID vaccine was designed to make an astronomical amount of money in a time of extreme inflation. If it made society better by "preventing infectious disease" that was a side-effect.

cantSpellSober 4y ago

Opioid addiction is a malignant disease, what's wrong with the usage here?

CoastalCoder 4y ago
We usually think of vaccines as medicines that train the immune system to attack unwelcome molecules / microbes. Perhaps the parent was asking if this technique actually uses the immune system? (From skimming the article, I think the answer is yes.)
- cantSpellSober 4y ago
  In the 8th sentence it says the vaccine will "generate anti-fentanyl antibodies" with the goal of preventing mental illness.

neuronexmachina 4y ago

The study's intro explains the use of the term: https://www.mdpi.com/1999-4923/14/11/2290/htm https://www.mdpi.com/1999-4923/14/11/2290/htm > OUD [Opioid Use Disorder] is a chronic disorder that even with maintenance therapy has relapse rates approaching 90% largely due to poor medication compliance with current agents [17,18]. Immunotherapy using vaccines can reduce this compliance problem by requiring less frequent administration. Vaccine immunotherapy targets small molecule antigens such as opioid compounds consisting of the antigen (hapten) linked to an immunogenic carrier protein that stimulates the immune system to generate antibodies. An adjuvant is often added to the formulation to increase immunogenicity (antibody formation) against the hapten. After vaccination, when an opioid is consumed, antibodies bind to the target opioid in the periphery and prevent it from getting into the brain or affecting other organs. The kidneys subsequently eliminate bound drug from the body. Numerous pre-clinical studies targeting a broad range of opioids have demonstrated vaccine efficacy [16,19,20,21,22]. > Recent studies testing various formulations of anti-FEN vaccines show efficacy in attenuating the behavioral and lethal effects of FEN and its derivatives [23,24,25] including findings from our group [26]. Our vaccine formulation is composed of a FEN-like hapten containing a linker with a carboxyl moiety suitable for carbodiimide coupling chemistry to form amide bonds to lysine residues on the carrier protein CRM197, a genetically deactivated diphtheria toxin contained in several FDA-approved conjugate vaccines. We combined our conjugate (FEN-CRM) with an adjuvant derived from heat-labile enterotoxins from E. coli (LT) named dmLT or LT(R192G/L211A) that has been combined with other vaccines in several human clinical trials

orblivion 4y ago

I thought it seemed like a stretch to use that word, but from the article it sounds like the immune system literally attacks the fentanyl as if it's a pathogen.