4 ms·

This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only wa

This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only way to get high. If all opioids... So it makes opioids no longer available for pain relief... forever? ("vaccine"?). (Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain). It claims to block the ability to get high -- does it also block overdose potential? Or is this just going to lead to lots of people OD'ing as they try to take enough to get high? One way or another, it seems likely to lead to even greater harm as addicted people look for something else that does work. Honestly seems like a bad idea overall, based on wrong and unuseful ideas about the nature of addiction.

bt1a 4y ago
This is an incredible opportunity to save lives. You need to familiarize yourself with accidental opioid overdose deaths. Most people who die from a fentanyl overdose were not intending to ingest fentanyl. Fentanyl is often used to boost the strength of more expensive opioids sold on the street. Fentanyl is very cheap to produce compared to heroin or whatever is the flavor of the month pressed pill. People die because the recreational dose for an opioid like heroin isn't many orders of magnitude away from the LD50
- jrochkind1 4y ago
  I see what you mean, but: "Once feared, illicit fentanyl is now a drug of choice for many opioid users: People with opioid-use disorder are increasingly seeking out illicit fentanyl, often smoking it." https://www.nbcnews.com/health/health-news/feared-illicit-fentanyl-now-drug-choice-many-opioids-users-rcna40418 https://www.nbcnews.com/health/health-news/feared-illicit-fe... (I really do know that everything you read in popular media about drug use in general, and opioid use specifically, cannot necesssarily be trusted. But my understanding from several sources is that this is so. The fact that fentanyl is cheaper for the effect is a reason a user might choose it too, or it may simply be what is available, or affordable) Whether users are intentionally seeking and/or aware of getting fentanyl or not, I am saying that the consequences of making someone's dose not have the effect they are looking for can often be that they take more (getting more of all of the substances that were in the dose, known or unknown), or that they switch to an alternate supply/substance. Either of which can have very dangerous outcomes. I won't tell you what you need to familiarize yourself with, or assume I know what you are or are not familiar with.
adam-a 4y ago
> “The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile. Not really clear if it prevents ODing but the article says: > Our vaccine is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys.
gwbas1c 4y ago
> Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain I had rather major surgery. Once I was sent home, the opioids just weren't worth it. (I was surprised.) Ibuprofen actually worked a lot better. Granted, I don't think I'd want to undergo surgery without opioids during the first few days of recovery.
ivanbakel 4y ago
>This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? This is answered in the article. >“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile. >Problems either way; if just fentanyl, then, duh, that's not the only way to get high. Yes, but fentanyl is considerably more dangerous than most of those other methods. Mis-judging your poorly-cut heroin dose by a milligram at least doesn't kill you. That's part of the point of targeting fentanyl itself with a vaccine - it would be accepted by the drug-taking public, because most of them don't want to be taking fentanyl in the first place: there are other ways to get high.
- jrochkind1 4y ago
  Does the vaccine make fentanyl less dangerous then, does it keep you from OD'ing on it?

bt1a 4y ago

This is an incredible opportunity to save lives. You need to familiarize yourself with accidental opioid overdose deaths. Most people who die from a fentanyl overdose were not intending to ingest fentanyl. Fentanyl is often used to boost the strength of more expensive opioids sold on the street. Fentanyl is very cheap to produce compared to heroin or whatever is the flavor of the month pressed pill. People die because the recreational dose for an opioid like heroin isn't many orders of magnitude away from the LD50

jrochkind1 4y ago
I see what you mean, but: "Once feared, illicit fentanyl is now a drug of choice for many opioid users: People with opioid-use disorder are increasingly seeking out illicit fentanyl, often smoking it." https://www.nbcnews.com/health/health-news/feared-illicit-fentanyl-now-drug-choice-many-opioids-users-rcna40418 https://www.nbcnews.com/health/health-news/feared-illicit-fe... (I really do know that everything you read in popular media about drug use in general, and opioid use specifically, cannot necesssarily be trusted. But my understanding from several sources is that this is so. The fact that fentanyl is cheaper for the effect is a reason a user might choose it too, or it may simply be what is available, or affordable) Whether users are intentionally seeking and/or aware of getting fentanyl or not, I am saying that the consequences of making someone's dose not have the effect they are looking for can often be that they take more (getting more of all of the substances that were in the dose, known or unknown), or that they switch to an alternate supply/substance. Either of which can have very dangerous outcomes. I won't tell you what you need to familiarize yourself with, or assume I know what you are or are not familiar with.

adam-a 4y ago

> “The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile. Not really clear if it prevents ODing but the article says: > Our vaccine is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys.

gwbas1c 4y ago

> Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain I had rather major surgery. Once I was sent home, the opioids just weren't worth it. (I was surprised.) Ibuprofen actually worked a lot better. Granted, I don't think I'd want to undergo surgery without opioids during the first few days of recovery.

ivanbakel 4y ago

>This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? This is answered in the article. >“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile. >Problems either way; if just fentanyl, then, duh, that's not the only way to get high. Yes, but fentanyl is considerably more dangerous than most of those other methods. Mis-judging your poorly-cut heroin dose by a milligram at least doesn't kill you. That's part of the point of targeting fentanyl itself with a vaccine - it would be accepted by the drug-taking public, because most of them don't want to be taking fentanyl in the first place: there are other ways to get high.

jrochkind1 4y ago
Does the vaccine make fentanyl less dangerous then, does it keep you from OD'ing on it?