4 ms·

> I think the overuse of antibiotics on cattle has had much less to do with drug resistant human gonorrhea than giving populations humans who have gonorrhea ins

> I think the overuse of antibiotics on cattle has had much less to do with drug resistant human gonorrhea than giving populations humans who have gonorrhea insufficient quantities of inadequate antibiotics, particularly incomplete courses or treatment of cases without followthrough.That creates a perfect informal laboratory for developing strains of drug resistant bugs. This is provably incorrect. The standard treatment protocol for gonorrhea is a single IM dose. There's no such thing as an "incomplete" treatment for gonorrhea. > We have subpopulations and particular communities who engage in "way more than their share" of risky sexual behavior, many of whom also use drugs and alcohol liberally, and in the worst cases (like say drug addiction/mental illness) don't generally seek medical care or otherwise take care of themselves. It's common and perhaps tempting to lump "people who have a lot of sex" together with "people who use drugs and alcohol" and "people who don't seek medical care or take care of themselves", but the data shows that that's not actually the case. Particularly for the subpopulations most affected by gonorrhea, where the data very clearly and unambiguously shows the opposite relationship.

inglor_cz 4y ago
"Particularly for the subpopulations most affected by gonorrhea, where the data very clearly and unambiguously shows the opposite relationship." People who tend to be sober and care about prophylactic care are the most afflicted with gonorrhoea?
- fsckboy 4y ago
  > People who tend to be sober and care about prophylactic care are the most afflicted with gonorrhoea? Thx! this made me laugh, I mean really :) >It's common and perhaps tempting to lump "people who have a lot of sex" together with "people who use drugs and alcohol" and "people who don't seek medical care or take care of themselves" Has he ever been out clubbing in NYC or LA or SF bars and nightclubs on any weekend night? and many more nights of the week? do we think there is alcohol and drugs and resulting sex there? Has he ever engaged a series of prostitutes? Do drug addicts need money? Where do they get it, what's an easy unskilled job? Think there's a higher %age of gonorrhea on Tinder or among those dedicated to going out and partying? Are people who've been drinking more likely to have sex or not? Are there hookup apps that result in a much higher hit rate for unprotected sex than Tinder that people who go out and party use?
fsckboy 4y ago
> This is provably incorrect. The standard treatment protocol for gonorrhea is a single IM dose. There's no such thing as an "incomplete" treatment for gonorrhea. that is no longer true, the standard treatment protocol is multiple doses now, and it's the exact same treatment for chlamydia which is very common, and would lead to the same "spillover" development of resistant strains of both. And even if you have taken the prescribed dose whether it's one or multiple, if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. to most likely develop a resistant strain, you have to have the antibiotic and the infection strains in the same body, it's not random.
- chimeracoder 4y ago
  > that is no longer true, the standard treatment protocol is multiple doses now, and it's the exact same treatment for chlamydia which is very common Incorrect. The standard treatment protocol for uncomplicated gonorrhea is a single IM ceftriaxone shot. The standard treatment protocol for chlamydia is a one-week oral doxycycline regimen. They are completely different treatments. Treatment adherence is an potential issue for the chlamydia course, but not for gonorrhea, because it is administered as a single shot. > and would lead to the same "spillover" development of resistant strains of both. On the contrary, the treatment protocols were specifically constructed to avoid this. > if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. That's technically true, but thankfully not particularly relevant, as most people aren't re-exposing themselves to gonorrhea within a few hours after being treated for it.
  - fsckboy 4y ago
    >> if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. >That's technically true, but thankfully not particularly relevant, as most people aren't re-exposing themselves to gonorrhea within a few hours after being treated for it. It doesn't matter what most people do, it only matters what the petri dishes for gain-of-function gonorrhea are doing. Resistant gonorrhea didn't appear quickly, and it didn't appear magically, it appeared after a sufficient number of people had both the pathogen and the antibiotic in their bodies, and the more times the better. We simply need to explain the behavior of those people.

inglor_cz 4y ago

"Particularly for the subpopulations most affected by gonorrhea, where the data very clearly and unambiguously shows the opposite relationship." People who tend to be sober and care about prophylactic care are the most afflicted with gonorrhoea?

fsckboy 4y ago
> People who tend to be sober and care about prophylactic care are the most afflicted with gonorrhoea? Thx! this made me laugh, I mean really :) >It's common and perhaps tempting to lump "people who have a lot of sex" together with "people who use drugs and alcohol" and "people who don't seek medical care or take care of themselves" Has he ever been out clubbing in NYC or LA or SF bars and nightclubs on any weekend night? and many more nights of the week? do we think there is alcohol and drugs and resulting sex there? Has he ever engaged a series of prostitutes? Do drug addicts need money? Where do they get it, what's an easy unskilled job? Think there's a higher %age of gonorrhea on Tinder or among those dedicated to going out and partying? Are people who've been drinking more likely to have sex or not? Are there hookup apps that result in a much higher hit rate for unprotected sex than Tinder that people who go out and party use?

fsckboy 4y ago

> This is provably incorrect. The standard treatment protocol for gonorrhea is a single IM dose. There's no such thing as an "incomplete" treatment for gonorrhea. that is no longer true, the standard treatment protocol is multiple doses now, and it's the exact same treatment for chlamydia which is very common, and would lead to the same "spillover" development of resistant strains of both. And even if you have taken the prescribed dose whether it's one or multiple, if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. to most likely develop a resistant strain, you have to have the antibiotic and the infection strains in the same body, it's not random.

chimeracoder 4y ago
> that is no longer true, the standard treatment protocol is multiple doses now, and it's the exact same treatment for chlamydia which is very common Incorrect. The standard treatment protocol for uncomplicated gonorrhea is a single IM ceftriaxone shot. The standard treatment protocol for chlamydia is a one-week oral doxycycline regimen. They are completely different treatments. Treatment adherence is an potential issue for the chlamydia course, but not for gonorrhea, because it is administered as a single shot. > and would lead to the same "spillover" development of resistant strains of both. On the contrary, the treatment protocols were specifically constructed to avoid this. > if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. That's technically true, but thankfully not particularly relevant, as most people aren't re-exposing themselves to gonorrhea within a few hours after being treated for it.
- fsckboy 4y ago
  >> if you are re-exposing yourself with varying half-lives of the antibiotics in your body, you are conducting experiments. >That's technically true, but thankfully not particularly relevant, as most people aren't re-exposing themselves to gonorrhea within a few hours after being treated for it. It doesn't matter what most people do, it only matters what the petri dishes for gain-of-function gonorrhea are doing. Resistant gonorrhea didn't appear quickly, and it didn't appear magically, it appeared after a sufficient number of people had both the pathogen and the antibiotic in their bodies, and the more times the better. We simply need to explain the behavior of those people.