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Journal article: Wu et al., "11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test valida
by jessriedel 4y ago
Journal article: Wu et al., "11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes"
https://assets.researchsquare.com/files/rs-1179128/v1_covered.pdf?c=1640793911 https://assets.researchsquare.com/files/rs-1179128/v1_covere...
Metomidate is a molecule (C_13 H_14 N_2 O_2) that naturally collects in the adrenal glands, and 11C-metomidate is a version where some of the carbon atoms are carbon-11, a radioactive version that will show up on PET-CT scans.
https://en.wikipedia.org/wiki/Metomidate https://en.wikipedia.org/wiki/Metomidate
For reference, a PET-CT scan costs $1k-$10k in the US. Not sure how much the radioactive tracer adds.
- pfdietz 4y agoThat tracer has to be made on site, since 11C has a halflife of 20 minutes. So there has to be a particle accelerator to make the 11C and a chemistry lab to quickly get the 11C into the drug.
- yencabulator 4y agoFun video of one such site: https://www.youtube.com/watch?v=eMTZvA8iFgI https://www.youtube.com/watch?v=eMTZvA8iFgI