This appears to be the actual CCSA study that led to the "no safe amount" conclusion: https://www.ccsa.ca/canadas-guidance-alcohol-and-health-final-report https

This appears to be the actual CCSA study that led to the "no safe amount" conclusion: https://www.ccsa.ca/canadas-guidance-alcohol-and-health-final-report https://www.ccsa.ca/canadas-guidance-alcohol-and-health-fina... I haven't read the report in detail so I can't comment on the methodology. Some salient points: • I don't see an actual recommendation that no alcohol is safe. The conclusion is that there is a continuum of risk, and that 3-6 drinks per week carries "moderate" risk. • The risk model output is presented on Pages 25 (females) and 26 (males). • The risk model appears to include both long-term health risks as well as short-term risks such as injury due to accident or violence that occurred while intoxicated with alcohol. • The risk model is developed using meta-analysis of several pre-existing studies. • The "2 drinks or less" recommendation is shown on the chart on Page 29, which shows the lifetime risk of year-of-life-lost as an increasing function of weekly average alcohol consumption. 2 drinks is approximately the crossover point where the risk goes above baseline.