I have no issues working with Docker/Python on a M1 Macbooks. Docker Desktop/Colima does the job well, and most of the images I use are available on arm. Runnin

I have no issues working with Docker/Python on a M1 Macbooks. Docker Desktop/Colima does the job well, and most of the images I use are available on arm. Running amd64 images is slower, but works well. For Python, Python itself is rarely the problem, but more often some older libraries that don't have wheels for M1 Mac, or incompatibilities. Upgrading your dependencies, if it's an option, is often enough. Asdf + PDM are also nice tools to work with multiple projects/Py versions easily.