3 ms·
Due to a past experiment in my lab by a post doc, I'll be forever skeptical of putative treatments for complex human diseases that were identified using rodent
by subroutine 4y ago
Due to a past experiment in my lab by a post doc, I'll be forever skeptical of putative treatments for complex human diseases that were identified using rodent models that target a narrowly defined set of behaviors or phenotypes.
The experiment was to test whether vitamin D supplements could attenuate behavioral problems associated with fetal alcohol syndrome. Our lab used a rat model of FAS. When the post doc told me about her experiment idea, I (as an undergrad at the time) told her it was interesting but couldn't be performed in a rat model because vitamin D was poison to rats. It calcifies their skin because they cant break D down like humans can. My warning was ignored, and the experiment was conducted anyway. She found that vitamin D treatment mitigated hyperactivity associated with FAS, and presented this finding at conferences. Well no shit this treatment would reduce activity in rats. If my skin was calcified I wouldn't want to move either.