Not necessarily, IgG4 is a unique case: > In a setting of HIV vaccination, a study compared repeated immunizations with two related HIV vaccine formats. The au

Not necessarily, IgG4 is a unique case: > In a setting of HIV vaccination, a study compared repeated immunizations with two related HIV vaccine formats. The authors described that the protection of one vaccine composition correlated with the induction of IgG1 and IgG3 Abs, whereas the other vaccine composition hardly showed any protection, which correlated with the generation of IgG4 upon repeated immunizations instead.