> using Retinol cream on my skin There’s a small chance it increases your chance of death [1] Results: The intervention was terminated 6 months early because

> using Retinol cream on my skin There’s a small chance it increases your chance of death [1] Results: The intervention was terminated 6 months early because of an excessive number of deaths in the tretinoin-treated group. Post hoc analysis of this difference revealed minor imbalances in age, comorbidity, and smoking status, all of which were important predictors of death. After adjusting for these imbalances, the difference in mortality between the randomized groups remained statistically significant. Conclusions: We observed an association of topical tretinoin therapy with death, but we do not infer a causal association that current evidence suggests is unlikely. 1. https://pubmed.ncbi.nlm.nih.gov/19153339/ https://pubmed.ncbi.nlm.nih.gov/19153339/