3 ms·

The National Institute on Aging has been doing this type of work for 20 years—-but systematically. The NIA Interventions Testing Program is now up to 20,000 mic

The National Institute on Aging has been doing this type of work for 20 years—-but systematically. The NIA Interventions Testing Program is now up to 20,000 mice and many many rational interventional drugs have been tested—-some in combination. The big hit is rapamycin, but there are several orhers. See: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp https://www.nia.nih.gov/research/dab/interventions-testing-p... We published initial genetic results from the first 3500 animals in Science this Sept (2022). See: https://pubmed.ncbi.nlm.nih.gov/36173858/ https://pubmed.ncbi.nlm.nih.gov/36173858/

xiphias2 4y ago
Looks amazing, thanks! I don't know why it doesn't have more visibility. I think one of the difference in goals is that interventions testing program repurposes approved drugs, while robust mouse rejuvenation is experimenting with unapproved drugs that have potential to both make mice live longer and translate into humans (thereby having a higher chance of rejuvenating mice) Both are great and important projects, I'm just hoping that they fight together instead of against eachother.