3 ms·

So the next thing to do is see how long you can keep mice alive then right? If this can reverse aging, can we keep mice alive indefinitely?

qup 4y ago
My thought was to take the old mouse, make it young again, and then make it old again. And sure, keep the brother 10 months old forever, but that takes a long time.
- jliptzin 4y ago
  It can be like the pitch drop experiment but for mice
xiphias2 4y ago
Aubrey de Gray just shared the details a mouse rejuvenation project last week that tests multiple compounds together. It uses 1000 mice, so it costs a lot, but finally there's enough money and data to start the mouse rejuvenation project.
- agumonkey 4y ago
  I assume this is it https://www.lifespan.io/news/aubrey-de-grey-on-levf-and-robust-mouse-rejuvenation/ https://www.lifespan.io/news/aubrey-de-grey-on-levf-and-robu...
  - xiphias2 4y ago
    Yes
    - agumonkey 4y ago
      Thanks for the tip nonetheless
- bitwize 4y ago
  [flagged]
- robwwilliams 4y ago
  The National Institute on Aging has been doing this type of work for 20 years—-but systematically. The NIA Interventions Testing Program is now up to 20,000 mice and many many rational interventional drugs have been tested—-some in combination. The big hit is rapamycin, but there are several orhers. See: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp https://www.nia.nih.gov/research/dab/interventions-testing-p... We published initial genetic results from the first 3500 animals in Science this Sept (2022). See: https://pubmed.ncbi.nlm.nih.gov/36173858/ https://pubmed.ncbi.nlm.nih.gov/36173858/
  - xiphias2 4y ago
    Looks amazing, thanks! I don't know why it doesn't have more visibility. I think one of the difference in goals is that interventions testing program repurposes approved drugs, while robust mouse rejuvenation is experimenting with unapproved drugs that have potential to both make mice live longer and translate into humans (thereby having a higher chance of rejuvenating mice) Both are great and important projects, I'm just hoping that they fight together instead of against eachother.

qup 4y ago

My thought was to take the old mouse, make it young again, and then make it old again. And sure, keep the brother 10 months old forever, but that takes a long time.

jliptzin 4y ago
It can be like the pitch drop experiment but for mice

xiphias2 4y ago

Aubrey de Gray just shared the details a mouse rejuvenation project last week that tests multiple compounds together. It uses 1000 mice, so it costs a lot, but finally there's enough money and data to start the mouse rejuvenation project.

agumonkey 4y ago
I assume this is it https://www.lifespan.io/news/aubrey-de-grey-on-levf-and-robust-mouse-rejuvenation/ https://www.lifespan.io/news/aubrey-de-grey-on-levf-and-robu...
- xiphias2 4y ago
  Yes
  - agumonkey 4y ago
    Thanks for the tip nonetheless
bitwize 4y ago
[flagged]
robwwilliams 4y ago
The National Institute on Aging has been doing this type of work for 20 years—-but systematically. The NIA Interventions Testing Program is now up to 20,000 mice and many many rational interventional drugs have been tested—-some in combination. The big hit is rapamycin, but there are several orhers. See: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp https://www.nia.nih.gov/research/dab/interventions-testing-p... We published initial genetic results from the first 3500 animals in Science this Sept (2022). See: https://pubmed.ncbi.nlm.nih.gov/36173858/ https://pubmed.ncbi.nlm.nih.gov/36173858/
- xiphias2 4y ago
  Looks amazing, thanks! I don't know why it doesn't have more visibility. I think one of the difference in goals is that interventions testing program repurposes approved drugs, while robust mouse rejuvenation is experimenting with unapproved drugs that have potential to both make mice live longer and translate into humans (thereby having a higher chance of rejuvenating mice) Both are great and important projects, I'm just hoping that they fight together instead of against eachother.