The article researches concentrations of BDNF following exercise and fasting: the link to neurodegenerative disorders is hypotetical. > Six minutes of high-int

The article researches concentrations of BDNF following exercise and fasting: the link to neurodegenerative disorders is hypotetical. > Six minutes of high-intensity exercise could extend the lifespan of a healthy brain and delay the onset of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease ... a short but intense bout of cycling increases the production of a specialized protein[: ]essential for brain formation, learning and memory, ... brain-derived neurotrophic factor (BDNF) promotes neuroplasticity... and the survival of neurons > BDNF increased ... more compared to fasting (no change in BDNF concentration) or prolonged activity (slight increase in BDNF concentration) > Twelve physically active participants... took part in the study -- Original research article: Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans - https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP283582 https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP283582 > Intermittent fasting and exercise provide neuroprotection from age-related cognitive decline. A link between these two seemingly distinct stressors is their capability to steer the brain away from exclusively glucose metabolism > [*] Intermittent fasting and exercise both have potent neuroprotective effects and an acute upregulation of brain-derived neurotrophic factor (BDNF) appears to be a common mechanistic link. [*] Switching the brain's fuel source from glucose to either ketone bodies or lactate, i.e. a cerebral substrate switch, has been shown to promote BDNF production in the rodent brain. [*] Fasting for 20 h caused a 9-fold increase in ketone body delivery to the brain but had no effect on any metric of BDNF in peripheral circulation at rest. [*] Prolonged (90 min) light cycling exercise increased plasma- and serum-derived BDNF irrespective of being fed or fasted and seemed to be independent of changes in cerebral shear stress. [*] Six minutes of high-intensity cycling intervals increased every metric of circulating BDNF by 4 to 5 times more than prolonged low-intensity cycling; the increase in plasma-derived BDNF was correlated with a 6-fold increase in circulating lactate irrespective of feeding or fasting. [*] Compared to 1 day of fasting with or without prolonged light exercise, high-intensity exercise is a much more efficient means to increase BDNF in circulation -- Note owing to the current times: these abridgements, normally opening my submissions, for the convenience of the reader and for the writer's purpose of analyzing the matter, are created by an actual intelligence (as opposed to automated).