That all derives from the fact that set and setting are crucial. And I didn't suggest worsening was likely, but I think it's about just as likely as stumbling

That all derives from the fact that set and setting are crucial. And I didn't suggest worsening was likely, but I think it's about just as likely as stumbling into a real treatment effect by accident, which is what I said. I'm not sure what data exists on the relative probabilities here, probably fairly little. Most of the time, you'll just achieve nothing at all other than maybe an afterglow that makes you think you're better for a couple of weeks. I've used a lot of different psychedelics in different settings over the years(pribably somewhere around 100 experiences with something like 10 different psychedelic drugs), Exactly once I've had a concrete, non-temporary improvement in mental health. Another time I had such a bad experience I took me months to properly recover. Most of the times I felt like progress was being made, but it turned out just to be an afterglow effect that quickly went away.