8 ms·

Those graphs in the article look too close to placebo. So I wonder why antidepressants are still prescribed to treat any kind of disorder and not only, well, ge

Those graphs in the article look too close to placebo. So I wonder why antidepressants are still prescribed to treat any kind of disorder and not only, well, genuine psychogenic depression. The thing is psychogenic aspect is overrated. In reality, there are multitudes of other pathologies that may cause a condition. For instance, metabolic dysfunction, poisoning, Lyme disease. And if one treats only the consequence and not the cause then the probability of a successful recovery becomes negligible.

kzrdude 4y ago
Should we do more comparisons to no treatment? (Placebo is not "no treatment", that's why we have placebo effect.) Three cohorts, medication, placebo medication, no treatment. There must have been studies like this? This metastudy seems to say they have no evidence of a placebo effect, though. https://pubmed.ncbi.nlm.nih.gov/12535498/ https://pubmed.ncbi.nlm.nih.gov/12535498/
gruez 4y ago
> Those graphs in the article look too close to placebo. So I wonder why antidepressants are still prescribed to treat any kind of disorder and not only, well, genuine psychogenic depression. Another article goes deeper into this issue (ie. why do meta-studies show a statistically significant difference, but the difference is so small?) https://awaisaftab.substack.com/p/the-case-for-antidepressants-in-2022 https://awaisaftab.substack.com/p/the-case-for-antidepressan...