4 ms·

According to Eric Weinstein, the breeding of lab animals specifically for use in testing drugs resulted in non-typical genetics, which invalidates most of the t

According to Eric Weinstein, the breeding of lab animals specifically for use in testing drugs resulted in non-typical genetics, which invalidates most of the testing they were used in anyway. Wild mice have different genetics than those fed mouse chow for generations, and bred for economic production.

_Wintermute 4y ago
That doesn't make much sense, you're not testing for efficacy in general mice populations. Both wild and lab-bred mice have different genetics to humans anyway.
jjtheblunt 4y ago
Who is Eric Weinstein?
- Our_Benefactors 4y ago
  A member of the USA intelligentsia.
- mikewarot 4y ago
  The wrong brother... I should have said Bret Weinstein oops
witheld 4y ago
Well, just get an intern to put out traps and get some wild ones!
JumpCrisscross 4y ago
> the breeding of lab animals specifically for use in testing drugs resulted in non-typical genetics, which invalidates most of the testing they were used in anyway I thought they were bred atypically so that they could serve as a uniform test environment? (Zero expertise in this field.)
- Vecr 4y ago
  Yes, lab mice are inbred and you can get ones very similar in most places, to replicate studies, etc. Similar to standard cell cultures.
refurb 4y ago
These are safety not efficacy studies. Unless inbreeding somehow made these lab animals immune from toxicity they are still good models.
- mikewarot 4y ago
  The breeding DID increase their ability to repair damage to toxicity, at the cost of all getting cancer, but after the age at which they were bred to live to. If you take a wild mouse, and feed it, it'll live a long time, the lab mice will eventually get cancer everywhere, and die of cancer. (or so the claim goes)
  - refurb 4y ago
    Do you have a source to show that inbreed mice have higher resistance to toxic drugs? I’d be interested to read it.
    - mikewarot 4y ago
      I'm relaying what I understand to be the truth, which obviously could be wrong. The pieces seem to be out there, as near as I (a person who never studied biology) can tell Example: https://journals.sagepub.com/doi/full/10.1177/10915818211009844 https://journals.sagepub.com/doi/full/10.1177/10915818211009... Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres The abstract discusses telomere length and sensitivity to arsenic toxicity. If my understanding is wrong, I'd be interested in guidance to correct it. I'm interested in understanding how things really work, and Weinstein's explanations (before the Covid thing hit) made sense of otherwise paradoxical facts.

_Wintermute 4y ago

That doesn't make much sense, you're not testing for efficacy in general mice populations. Both wild and lab-bred mice have different genetics to humans anyway.

jjtheblunt 4y ago

Who is Eric Weinstein?

Our_Benefactors 4y ago
A member of the USA intelligentsia.
mikewarot 4y ago
The wrong brother... I should have said Bret Weinstein oops

witheld 4y ago

Well, just get an intern to put out traps and get some wild ones!

JumpCrisscross 4y ago

> the breeding of lab animals specifically for use in testing drugs resulted in non-typical genetics, which invalidates most of the testing they were used in anyway I thought they were bred atypically so that they could serve as a uniform test environment? (Zero expertise in this field.)

Vecr 4y ago
Yes, lab mice are inbred and you can get ones very similar in most places, to replicate studies, etc. Similar to standard cell cultures.

refurb 4y ago

These are safety not efficacy studies. Unless inbreeding somehow made these lab animals immune from toxicity they are still good models.

mikewarot 4y ago
The breeding DID increase their ability to repair damage to toxicity, at the cost of all getting cancer, but after the age at which they were bred to live to. If you take a wild mouse, and feed it, it'll live a long time, the lab mice will eventually get cancer everywhere, and die of cancer. (or so the claim goes)
- refurb 4y ago
  Do you have a source to show that inbreed mice have higher resistance to toxic drugs? I’d be interested to read it.
  - mikewarot 4y ago
    I'm relaying what I understand to be the truth, which obviously could be wrong. The pieces seem to be out there, as near as I (a person who never studied biology) can tell Example: https://journals.sagepub.com/doi/full/10.1177/10915818211009844 https://journals.sagepub.com/doi/full/10.1177/10915818211009... Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres The abstract discusses telomere length and sensitivity to arsenic toxicity. If my understanding is wrong, I'd be interested in guidance to correct it. I'm interested in understanding how things really work, and Weinstein's explanations (before the Covid thing hit) made sense of otherwise paradoxical facts.