The bioinformatics scene is generally legacy in the good way, like how bash tooling is legacy: consistent and highly modular. Sure, the tool you are using might

The bioinformatics scene is generally legacy in the good way, like how bash tooling is legacy: consistent and highly modular. Sure, the tool you are using might not be able to support compressed data or some new compression algorithm, but then so what, you can just add whatever hotnewcompression tool before and after this tool in your pipeline, and throttle the work to maximize available storage and compute. Many pipelines are written simply in bash, or use something like snakemake or nextflow to ensure consistent environments.