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Falling back again to the research done by Levin lab, they are able to shape 2-headed or 2-tailed flatworms by altering electric potential differences, and thes
by ly3xqhl8g9 4y ago
Falling back again to the research done by Levin lab, they are able to shape 2-headed or 2-tailed flatworms by altering electric potential differences, and these flatworms have the same DNA as the regular one head, one tail flatworm [1]. See them in video [2].
One other lesson to be learned from the planarian flatworms is that their DNA is a complete mess, yet they are able to fully regenerate without any issues, and are functionally immortal, they do not age [3].
DNA is certainly important and interesting and needs more research, my initial comment just pointed out that if DNA is a "CAD model", the computational layer, the basal cognition in cell/tissue/organ(ism), is even more enticing, and probably we don't even need to alter genes in order to shape morphology, giving another analogy, if a pocket calculator "knows" what 5 + 7 is, we probably don't need to build another pocket calculator just to compute 6 + 8.
[1] A Computational Approach to Explaining Bioelectrically Induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration, https://www.liebertpub.com/doi/10.1089/bioe.2021.0036 https://www.liebertpub.com/doi/10.1089/bioe.2021.0036
[2] Endogenous Bioelectric Networks & Regenerative Medicine, https://www.youtube.com/watch?v=HKWyB9qLP_s https://www.youtube.com/watch?v=HKWyB9qLP_s (Impossible Biological Objects, 2-headed flatworms at 52:30)
[3] Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696462/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696462/